Prions or PrP^Sc (prion protein, Scrapie isoform) are proteins with an aberrant three-dimensional conformation that present the ability to alter the three-dimensional structure of natively folded PrP^C (prion protein, cellular isoform) inducing its abnormal folding, giving raise to neurological diseases known as Transmissible spongiforms encephalopathies (TSEs) or prion diseases. In this work, through a biosemiotic study, we will analyze the molecular code of meanings that are known in the molecular pathway of PrP^C and how it is altered in prion diseases. This biosemiotic code presents a socio-semiotic correlate in organisms that could be unraveled with the ultimate goal of understanding the code of signs that mediates the process. Finally, we will study recent works that indicate possible relationships in the code between prion proteins and other proteins such as the tau protein and alpha-synuclein to evaluate if it is possible that there is a semiotic expansion of the PrP code and prion diseases in the meaning recently expounded by Prusiner, winner of the Nobel Prize for describing these unusual pathological processes.

朊病毒或 PrP ^Sc（朊病毒蛋白，Scrapie 同种型）是具有异常三维构象的蛋白质，能够改变天然折叠的 PrP ^C（朊病毒蛋白，细胞同种型）的三维结构，从而诱导其异常折叠，从而提高被称为传染性海绵状脑病 (TSE) 或朊病毒病的神经系统疾病。在这项工作中，通过生物符号学研究，我们将分析在 PrP ^{C的分子途径中已知的意义的分子代码。}以及它在朊病毒疾病中是如何改变的。这种生物符号学代码呈现了有机体中的社会符号学相关性，最终目标是理解介导这一过程的符号代码。最后，我们将研究表明朊病毒蛋白与其他蛋白质（如 tau 蛋白和 α-突触核蛋白）之间可能存在编码关系的近期工作，以评估 PrP 编码和朊病毒疾病是否存在符号学扩展。诺贝尔奖获得者普鲁西纳最近阐述了这些不寻常的病理过程。