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A high fat, sugar, and salt Western diet induces motor-muscular and sensory dysfunctions and neurodegeneration in mice during aging: Ameliorative action of metformin
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2021-09-12 , DOI: 10.1111/cns.13726
Song Hong 1, 2 , Aarti Nagayach 1 , Yan Lu 1 , Hongying Peng 3 , Quoc-Viet A Duong 1 , Nicholas B Pham 1 , Christopher A Vuong 1 , Nicolas G Bazan 1, 2
Affiliation  

To explore the novel linkage between a Western diet combining high saturated fat, sugar, and salt (HFSS) and neurological dysfunctions during aging as well as Metformin intervention, we assessed cerebral cortex abnormalities associated with sensory and motor dysfunctions and cellular and molecular insights in brains using HFSS-fed mice during aging. We also explored the effect of Metformin treatment on these mice.

中文翻译:

高脂肪、高糖和高盐的西方饮食在衰老过程中诱导小鼠运动肌肉和感觉功能障碍和神经退行性变:二甲双胍的改善作用

为了探索结合高饱和脂肪、糖和盐 (HFSS) 的西方饮食与衰老过程中的神经功能障碍以及二甲双胍干预之间的新联系,我们评估了与感觉和运动功能障碍相关的大脑皮层异常以及大脑中的细胞和分子洞察力在衰老过程中使用 HFSS 喂养的小鼠。我们还探讨了二甲双胍治疗对这些小鼠的影响。
更新日期:2021-09-12
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