Neutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway macrophages are long-lived immune cells that exert important homeostatic and inflammatory functions which are dysregulated in asthma. Unique transcriptomic programmes reflect varied macrophage phenotypes in vitro. We aimed to determine whether airway macrophages are transcriptomically altered in NA.

中文翻译：

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改变的痰巨噬细胞转录组有助于中性粒细胞哮喘内型

中性粒细胞哮喘 (NA) 是临床上重要的哮喘表型，其细胞和分子基础尚未完全清楚。气道巨噬细胞是长寿命的免疫细胞，它们发挥重要的稳态和炎症功能，在哮喘中失调。独特的转录组程序反映了体外不同的巨噬细胞表型。我们旨在确定气道巨噬细胞是否在 NA 中发生转录组改变。