Canola oil (Can) and several vegetable oils shorten the lifespan of stroke-prone spontaneously hypertensive rats (SHRSP). Although similar lifespan shortening has been reported for partially hydrogenated Can, the efficacy of fully hydrogenated oils on the lifespan remains unknown. The present study aimed to investigate the lifespan of SHRSP fed diets containing 10 % (w/w) of fully hydrogenated Can (FHCO) or other oils. Survival test: Upon weaning, male SHRSP were fed a basal diet for rodents mixed with one of the test oils —i.e., FHCO, Can, lard (Lrd), and palm oil (Plm) throughout the experiment. The animals could freely access the diet and drinking water (water containing 1 % NaCl), and their body weight, food intake, and lifespan were recorded. Biochemical analysis test: Male SHRSP were fed a test diet with either FHCO, Can, or soybean oil (Soy) under the same condition, except to emphasize effects of fat, that no NaCl loading was applied. Soy was used as a fat source in the basal diet and was set the control group. Blood pressures was checked every 2 weeks, and serum fat levels and histological analyses of the brain and kidney were examined after 7 or 12 weeks of feeding. During the survival study period, the food consumption of FHCO-fed rats significantly increased (15–20 % w/w) compared with that of rats fed any other oil. However, the body weight gain in the FHCO group was significantly less (10–12 %) than that in the control group at 9–11 weeks old. The FHCO (> 180 days) intervention had the greatest effect on lifespan, followed by the Lrd (115 ± 6 days), Plm (101 ± 2 days), and Can (94 ± 3 days) diets. FHCO remarkably decreased the serum cholesterol level compared with Can and the systolic blood pressure from 12 to 16 weeks of age. In addition, while some rats in the Can group exhibited brain hemorrhaging and renal dysfunction at 16 weeks old, no symptoms were observed in the FHCO group. This current study suggests that complete hydrogenation decreases the toxicity of Can and even prolongs the lifespan in SHRSP.

中文翻译：

---

全氢化菜籽油可延长易中风自发性高血压大鼠的寿命

菜籽油 (Can) 和几种植物油可缩短中风倾向的自发性高血压大鼠 (SHRSP) 的寿命。尽管已经报道了部分氢化罐的类似寿命缩短，但完全氢化油对寿命的功效仍然未知。本研究旨在调查 SHRSP 饲喂含有 10% (w/w) 全氢化罐头 (FHCO) 或其他油的日粮的寿命。生存测试：在断奶后，雄性 SHRSP 被喂食啮齿动物的基础饮食，并在整个实验过程中混合了一种测试油，即 FHCO、罐头油、猪油 (Lrd) 和棕榈油 (Plm)。动物可以自由获取饮食和饮用水（含有1% NaCl的水），并记录它们的体重、食物摄入量和寿命。生化分析测试：给雄性 SHRSP 喂食 FHCO、Can、或大豆油 (Soy) 在相同条件下，除了强调脂肪的影响，没有施加 NaCl 负载。大豆作为基础饮食中的脂肪来源，并作为对照组。每 2 周检查一次血压，并在喂食 7 或 12 周后检查血清脂肪水平和大脑和肾脏的组织学分析。在生存研究期间，与喂食任何其他油的大鼠相比，喂食 FHCO 的大鼠的食物消耗显着增加（15-20 % w/w）。然而，在 9-11 周龄时，FHCO 组的体重增加明显少于对照组（10-12%）。FHCO（> 180 天）干预对寿命的影响最大，其次是 Lrd（115 ± 6 天）、Plm（101 ± 2 天）和 Can（94 ± 3 天）饮食。与 Can 相比，FHCO 显着降低了 12 至 16 周龄的血清胆固醇水平和收缩压。此外，虽然 Can 组中的一些大鼠在 16 周龄时表现出脑出血和肾功能障碍，但在 FHCO 组中未观察到任何症状。目前的这项研究表明，完全氢化可降低 Can 的毒性，甚至延长 SHRSP 的寿命。