Lymph nodes (LNs) aid the interaction between lymphocytes and antigen-presenting cells, resulting in adequate and prolonged adaptive immune responses. LN stromal cells (LNSCs) are crucially involved in steering adaptive immune responses at different levels. Most knowledge on LNSCs has been obtained from mouse studies, and few studies indicate similarities with their human counterparts. Recent advances in single-cell technologies have revealed significant LNSC heterogeneity among different subsets with potential selective functions in immunity. This review provides an overview of current knowledge of LNSCs based on human and murine studies describing the role of these cells in health and disease.

淋巴结 (LN) 有助于淋巴细胞和抗原呈递细胞之间的相互作用，从而产生充分和延长的适应性免疫反应。LN 基质细胞 (LNSC) 在不同水平上参与引导适应性免疫反应至关重要。大多数关于 LNSCs 的知识是从小鼠研究中获得的，很少有研究表明与人类对应物有相似之处。单细胞技术的最新进展揭示了具有潜在免疫选择性功能的不同亚群之间显着的 LNSC 异质性。本综述概述了基于人类和鼠类研究的 LNSCs 的当前知识，这些研究描述了这些细胞在健康和疾病中的作用。