Patients with inflammatory bowel disease (IBD) have higher incidence of extraintestinal manifestations (EIM), including liver disorders, sarcopenia, and neuroinflammation. Fermented rice bran (FRB), generated from rice bran (RB), is rich in bioactive compounds, and exhibits anti–colitis activity. However, its role in EIM prevention is still unclear. Here, for the first time, we investigated whether EIM in female C57Bl/6N mice is attenuated by FRB supplementation. EIM was induced by repeated administration of 1.5% dextran sulfate sodium (DSS) in drinking water (4 d) followed by drinking water (12 d). Mice were divided into 3 groups—control (AIN93M), 10% RB, and 10% FRB. FRB ameliorated relapsing colitis and inflammation in muscle by significantly lowering proinflammatory cytokines Tnf-α and Il-6 in serum and advanced glycation end product-specific receptor (Ager) in serum and muscle when compared with the RB and control groups. As FRB reduced aspartate aminotransferase levels and oxidative stress, it might prevent liver disorders. FRB downregulated proinflammatory cytokine and chemokine transcripts responsible for neuroinflammation in the hippocampus and upregulated mRNA expression of G protein coupled receptors (GPRs), Gpr41 and Gpr43, in small and large intestines, which may explain the FRB-mediated protective mechanism. Hence, FRB can be used as a supplement to prevent IBD-associated EIM.

炎症性肠病 (IBD) 患者的肠外表现 (EIM) 发生率较高，包括肝脏疾病、肌肉减少症和神经炎症。由米糠 (RB) 产生的发酵米糠 (FRB) 富含生物活性化合物，并具有抗结肠炎活性。然而，其在 EIM 预防中的作用仍不清楚。在这里，我们首次研究了雌性 C57Bl/6N 小鼠的 EIM 是否因 FRB 补充剂而减弱。通过在饮用水中重复施用 1.5% 硫酸葡聚糖钠 (DSS)（4 天），然后是饮用水（12 天）来诱导 EIM。将小鼠分为 3 组——对照组 (AIN93M)、10% RB 和 10% FRB。与 RB 组和对照组相比，FRB 通过显着降低血清中的促炎细胞因子 Tnf-α 和 Il-6 以及血清和肌肉中的晚期糖基化终产物特异性受体 (Ager) 来改善复发性结肠炎和肌肉炎症。由于 FRB 降低了天冬氨酸氨基转移酶水平和氧化应激，它可能会预防肝脏疾病。FRB 下调负责海马神经炎症的促炎细胞因子和趋化因子转录物，并上调 G 蛋白偶联受体 (GPR) 的 mRNA 表达，小肠和大肠中的Gpr41和Gpr43，这可以解释 FRB 介导的保护机制。因此，FRB 可用作预防 IBD 相关 EIM 的补充。