Introduction

Cancer is the second major threat to human society and one of the main challenges facing healthcare systems. One of the main problems of cancer care is the metastases of cancer cells that cause 90% of deaths due to cancer. Multiple molecular mechanisms are involved in cancer cell metastasis. Therefore, a better understanding of these molecular mechanisms is necessary for designing restrictive strategies against cancer cell metastasis. Accumulating data suggests that MicroRNAs (miRNAs) are involved in metastasis and invasion of human tumors through regulating multiple genes expression levels that are involved in molecular mechanisms of metastasis. The goal of this review is to present the molecular pathways by which the miR 200 family manifests its effects on EMT, cancer stem cells, angiogenesis, anoikis, and the effects of tumor cell metastases.

Methods

A detailed literature search was conducted to find information about the role of the miR-200 family in the processes involved in metastasis in various databases.

Results

Numerous lines of evidence revealed an association between the mir-200 family and metastasis of human tumors by impressing processes such as cancer stem cells, EMT, angiogenesis, and anoikis.

Conclusions

Understanding the molecular mechanisms associated with metastasis in which the miR-200 family is involved can be effective in treating metastatic cancers.

Graphic abstract

中文翻译：

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miR-200 家族在转移中的新兴作用：关注 EMT、CSC、血管生成和失巢凋亡

介绍

癌症是人类社会面临的第二大威胁，也是医疗保健系统面临的主要挑战之一。癌症治疗的主要问题之一是癌细胞的转移，导致 90% 的癌症死亡。多种分子机制参与癌细胞转移。因此，更好地理解这些分子机制对于设计针对癌细胞转移的限制性策略是必要的。越来越多的数据表明，微小RNA（miRNA）通过调节参与转移分子机制的多个基因表达水平参与人类肿瘤的转移和侵袭。本综述的目的是介绍 miR 200 家族表现出其对 EMT、癌症干细胞、血管生成、失巢凋亡和肿瘤细胞转移的影响的分子途径。

方法

进行了详细的文献检索，以查找有关 miR-200 家族在各种数据库中涉及转移的过程中的作用的信息。

结果

大量证据表明 mir-200 家族与人类肿瘤转移之间存在关联，其影响过程包括癌症干细胞、EMT、血管生成和失巢凋亡等过程。

结论

了解 miR-200 家族参与的与转移相关的分​​子机制可有效治疗转移性癌症。

图形摘要