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Optogenetic Stimulation of the Anterior Cingulate Cortex Modulates the Pain Processing in Neuropathic Pain: A Review
Journal of Molecular Neuroscience ( IF 3.1 ) Pub Date : 2021-09-10 , DOI: 10.1007/s12031-021-01898-4
Hyeong Cheol Moon 1 , Young Seok Park 1, 2, 3
Affiliation  

Neuropathic pain is characterized by hypersensitivity, hyperalgesia, and allodynia, which is caused by damage to the somatosensory nervous system. It substantially impairs the quality of life. The management of neuropathic pain is challenging and should comprise alternative therapies. Researchers working on neural modulation methods in the field of optogenetics have recently referred to novel techniques that involve the activation or inhibition of signaling proteins by specific wavelengths of light. The use of optogenetics in neuropathic pain facilitates the investigation of pain pathways involved in chronic pain and has the potential for therapeutic use. Neuropathic pain is often accompanied by negative stimuli involving a broad network of brain regions. In particular, the anterior cingulate cortex (ACC) is a part of the limbic system that has highly interconnected structures involved in processing components of pain. The ACC is a key region for acute pain perception as well as the development of neuropathic pain, characterized by long-term potentiation induced in pain pathways. The exact mechanism for neuropathic pain in the ACC is unclear. Current evidence supports the potential of optogenetics methods to modulate the neuronal activity in the ACC for neuropathic pain. We anticipate the neuronal modulation in the ACC will be used widely to manage neuropathic pain.



中文翻译:

前扣带皮层的光遗传学刺激调节神经性疼痛的疼痛处理:综述

神经性疼痛的特点是过敏、痛觉过敏和异常性疼痛,这是由躯体感觉神经系统损伤引起的。它严重损害了生活质量。神经性疼痛的管理具有挑战性,应包括替代疗法。研究光遗传学领域神经调制方法的研究人员最近提到了新技术,这些技术涉及通过特定波长的光激活或抑制信号蛋白。光遗传学在神经性疼痛中的应用有助于研究慢性疼痛中涉及的疼痛通路,并具有治疗用途的潜力。神经性疼痛通常伴随着涉及广泛的大脑区域网络的负面刺激。特别是,前扣带回皮层 (ACC) 是边缘系统的一部分,具有高度互连的结构,参与处理疼痛成分。ACC 是急性疼痛感知以及神经性疼痛发展的关键区域,其特征是在疼痛通​​路中诱导的长期增强。ACC 神经性疼痛的确切机制尚不清楚。目前的证据支持光遗传学方法在调节 ACC 中神经元活动以治疗神经性疼痛方面的潜力。我们预计 ACC 中的神经元调制将被广泛用于治疗神经性疼痛。ACC 神经性疼痛的确切机制尚不清楚。目前的证据支持光遗传学方法在调节 ACC 中神经元活动以治疗神经性疼痛方面的潜力。我们预计 ACC 中的神经元调制将被广泛用于治疗神经性疼痛。ACC 神经性疼痛的确切机制尚不清楚。目前的证据支持光遗传学方法在调节 ACC 中神经元活动以治疗神经病理性疼痛方面的潜力。我们预计 ACC 中的神经元调制将被广泛用于治疗神经性疼痛。

更新日期:2021-09-12
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