Microscopic Portal Vein Invasion in Relation to Tumor Focality and Dimension in Patients with Hepatocellular Carcinoma,Journal of Gastrointestinal Surgery

当前位置： X-MOL 学术 › J. Gastrointest. Surg. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Microscopic Portal Vein Invasion in Relation to Tumor Focality and Dimension in Patients with Hepatocellular Carcinoma
Journal of Gastrointestinal Surgery ( IF 3.2 ) Pub Date : 2021-09-10 , DOI: 10.1007/s11605-021-05126-7
Brian I. Carr ₁ , Volkan Ince ₁ , Sami Akbulut ₁ , Veysel Ersan ₁ , Sertac Usta ₁ , Burak Isik ₁ , Sezai Yilmaz ₁ , Vito Guerra ₂ , Rossella Donghia ₂ , Emine Samdanci ₃

Affiliation

Background

Microscopic portal vein invasion (microPVI) and tumor multifocality are hepatocellular carcinoma (HCC) prognosis factors. To investigate whether microPVI and multifocality are directly related to each other.

Methods

We retrospectively analyzed the relationships between microPVI, multifocality, and maximum tumor diameter (MTD) in prospectively collected transplanted HCC patients.

Results

HCCs with 1, 2, or ≥ 3 foci had more microPVI in larger than in smaller HCCs, with microPVI being present in 52.24% of single large foci. Conversely, microPVI patients had similar percentages of single and multifocal lesions. A linear regression model of MTD, showed microPVI best associated with MTD, with 2.49 as coefficient, whereas multifocality had a 0.83 coefficient. A logistic regression model of microPVI showed significant association with tumor multifocality, especially for small HCCs. Trends for microPVI and multifocality in relation to MTD revealed that both increased with MTD but more significantly for microPVI. Survival was similar in patients with small HCCs, with or without microPVI, but was significantly worse in microPVI patients with larger HCCs. No patient survival differences were found in relation to focality.

Conclusions

MTD had stronger associations with microPVI than with multifocality. microPVI was associated with worse survival in patients with large HCCs, but survival was not impacted by number of tumor foci. microPVI and multifocality appear weakly related, having different behavior in relation to MTD and survival.

中文翻译：

肝细胞癌患者显微门静脉侵犯与肿瘤病灶和尺寸的关系

背景

显微门静脉侵犯 (microPVI) 和肿瘤多灶性是肝细胞癌 (HCC) 的预后因素。研究 microPVI 和多焦点是否直接相关。

方法

我们回顾性分析了前瞻性收集的移植 HCC 患者中 microPVI、多灶性和最大肿瘤直径 (MTD) 之间的关系。

结果

具有 1、2 或 ≥ 3 个病灶的 HCC 在较大的 HCC 中比在较小的 HCC 中具有更多的 microPVI，52.24% 的单个大病灶中存在 microPVI。相反，microPVI 患者的单灶和多灶病变比例相似。MTD 的线性回归模型显示 microPVI 与 MTD 的相关性最好，系数为 2.49，而多焦点的系数为 0.83。microPVI 的逻辑回归模型显示与肿瘤多灶性显着相关，尤其是对于小 HCC。与 MTD 相关的 microPVI 和多焦点趋势表明，两者都随着 MTD 增加，但对于 microPVI 更为显着。有或没有 microPVI 的小 HCC 患者的生存率相似，但在具有较大 HCC 的 microPVI 患者中生存率明显更差。没有发现与病灶有关的患者生存差异。