Nowadays, glycerol polyesters are willingly studied, due to their potential to use in tissue engineering and drug delivery systems. Poly(glycerol citrate) is a quite new material that could have very interesting properties because of the easy formation of three-dimensional hydrophilic networks. Moreover, both glycerol and citric acid are commonly used chemicals in the food and pharmaceutical industry. They are cheap, well available, and well-known substances. In this work poly(glycerol citrate) was synthesized in bulk polycondensation with water removal. The polyester structure was widely characterized by FTIR, NMR, GPC, and the end group titration methods. The synthesis procedure was optimized and described via five mathematical models with the use of the design of experiments. The presented method was developed for further industrial use and allows for avoiding gelling phenomena. Based on this work, poly(glycerol citrate) could be obtained with desired properties, moreover, the process is prepared for scaling-up.

中文翻译：

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通过实验设计优化生物基聚（甘油柠檬酸酯）合成

如今，人们愿意对甘油聚酯进行研究，因为它们具有用于组织工程和药物输送系统的潜力。聚（柠檬酸甘油酯）是一种非常新的材料，由于易于形成三维亲水网络，因此具有非常有趣的特性。此外，甘油和柠檬酸都是食品和制药行业常用的化学品。它们很便宜，很容易买到，并且是众所周知的物质。在这项工作中，聚（柠檬酸甘油酯）是通过本体缩聚反应合成的，并去除了水分。通过FTIR、NMR、GPC和端基滴定法对聚酯结构进行了广泛表征。利用实验设计，通过五个数学模型对合成过程进行了优化和描述。所提出的方法是为进一步工业用途而开发的，并允许避免胶凝现象。基于这项工作，可以获得具有所需特性的聚（柠檬酸甘油酯），此外，该工艺已准备好扩大规模。