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Effect of Water–Dimethylsulfoxide Solvent on the Solvation of Hydroxypropyl-β-cyclodextrine
Russian Journal of Physical Chemistry A ( IF 0.7 ) Pub Date : 2021-09-12 , DOI: 10.1134/s0036024421090107
N. N. Kuranova 1 , T. R. Usacheva 1 , A. S. Gushchina 1 , D. A. Alistair 1 , D. N. Kabirov 1 , L. Pham Thi 2
Affiliation  

Abstract

The distribution of a substance between two immiscible phases: a water–dimethylsulfoxide solvent of variable composition and n-hexane is studied. The obtained data are used to determine the distribution coefficients of hydroxypropyl-β-cyclodextrin and to calculate the changes in the Gibbs energy of resolvation. Weakening of the solvation of the macrocycle is observed upon moving from water to aqueous solutions of dimethylsulfoxide. Based on an analysis of the obtained and literature data, it is assumed that changes in the state of solvation of cyclodextrins have the main effect on the change in the stability of complexes of quercetin with hydroxypropyl-β-cyclodextrin and with β-cyclodextrin in water–dimethylsulfoxide solvent.



中文翻译:

水-二甲亚砜溶剂对羟丙基-β-环糊精溶剂化的影响

摘要

一种物质的两种不混溶相之间的分布:与可变组合物的水-二甲基亚砜溶剂Ñ正己烷进行了研究。获得的数据用于确定羟丙基-β-环糊精的分配系数并计算吉布斯分解能的变化。当从水转移到二甲亚砜的水溶液时,观察到大环的溶剂化减弱。基于对所得数据和文献数据的分析,假设环糊精溶剂化状态的变化对槲皮素与羟丙基-β-环糊精和β-环糊精在水中的复合物的稳定性变化有主要影响——二甲亚砜溶剂。

更新日期:2021-09-12
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