Bone marrow mesenchymal stromal cells (BMMSCs) are widely sourced and easily amplified in vitro; thus, they have a great potential in the treatment of hemopathies. Recent findings suggested that BMMSCs express the aryl hydrocarbon receptor (AHR). However, few studies have reported on the regulation of proliferative behaviors and metabolism by AHR in BMMSCs. In the present study, we found that activating AHR reduced the proliferation of BMMSCs and enhanced their mitochondrial function, whereas inhibiting AHR exerted the opposite effects. This study may provide the basis for further unveiling the molecular mechanisms and therapeutic potential of AHR in BMMSCs.

中文翻译：

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芳烃受体信号通路在骨髓间充质基质细胞的增殖和代谢特性中起重要作用。

骨髓间充质基质细胞 (BMMSCs) 来源广泛且易于体外扩增；因此，它们在治疗血液病方面具有巨大潜力。最近的研究结果表明，BMMSCs 表达芳烃受体 (AHR)。然而，很少有研究报道 AHR 在 BMMSCs 中对增殖行为和代谢的调节。在本研究中，我们发现激活 AHR 可减少 BMMSCs 的增殖并增强其线粒体功能，而抑制 AHR 则产生相反的作用。该研究可能为进一步揭示AHR在BMMSCs中的分子机制和治疗潜力提供基础。