Recurrent locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with dismal prognosis because of its highly invasive behavior and resistance to conventional intensive chemotherapy. The identification of effective markers for early diagnosis and prognosis is important for reducing mortality and ensuring that therapy for HNSCC is effective. Chaperonin-containing TCP-1 3 (CCT3) folds cancer-related proteins to control carcinogenesis. The prognostic value and growth association of CCT3 and HNSCC remains unknown.

中文翻译：

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将 CCT3 鉴定为预后因素并与头颈部鳞状细胞癌的细胞存活和侵袭相关。

复发性局部晚期或转移性头颈部鳞状细胞癌 (HNSCC) 与预后不良有关，因为它具有高度侵袭性和对常规强化化疗的抵抗力。识别早期诊断和预后的有效标志物对于降低死亡率和确保 HNSCC 的治疗有效很重要。含有伴侣蛋白的 TCP-1 3 (CCT3) 折叠癌症相关蛋白以控制致癌作用。CCT3 和 HNSCC 的预后价值和生长关联仍然未知。