The RNA binding proteins PCBP1 and PCBP2 are each essential for mouse development. Ji et al. (e00668-20) used conditional gene knockouts to explore roles of PCBP1 and PCBP2 in erythroid development. Ablation of each individual protein during erythroid differentiation in the mouse embryo failed to impact viability or blood formation, while their combined loss triggered midgestational repression of hematopoietic gene expression, loss of blood formation, and fetal demise. Orthogonal analyses in primary erythroid progenitors revealed that the two proteins mediate overlapping and isoform-specific impacts on the hematopoietic transcriptome. These data reveal that PCBPs play complex and essential roles in mammalian erythropoiesis.

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本期重要文章

RNA 结合蛋白 PCBP1 和 PCBP2 都是小鼠发育所必需的。季等。(e00668-20) 使用条件基因敲除来探索 PCBP1 和 PCBP2 在红细胞发育中的作用。在小鼠胚胎的红细胞分化过程中，每种蛋白质的消融未能影响生存能力或血液形成，而它们的联合损失引发了造血基因表达的妊娠中期抑制、血液形成的损失和胎儿死亡。原代红细胞祖细胞的正交分析表明，这两种蛋白质介导了对造血转录组的重叠和亚型特异性影响。这些数据表明 PCBPs 在哺乳动物红细胞生成中起着复杂而重要的作用。