Of Rats and Men, a Translational Model to Understand Vancomycin Pharmacokinetic/Toxicodynamic relationships.,Antimicrobial Agents and Chemotherapy

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Of Rats and Men, a Translational Model to Understand Vancomycin Pharmacokinetic/Toxicodynamic relationships.
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-08-02 , DOI: 10.1128/aac.01060-21
Marc H Scheetz _{1,

2,

3} , Gwendolyn M Pais _{1,

2} , Thomas P Lodise ₄ , Steven Y C Tong _{5,

6,

7} , Joshua S Davis ₇ , J Nicholas O'Donnell ₄ , Jiajun Liu ₈ , Michael Neely ₉ , Walter C Prozialeck ₃ , Peter C Lamar ₃ , Nathaniel J Rhodes _{1,

2} , Thomas Holland _{10,

11} , Sean N Avedissian _{12,

13}

Affiliation

Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern Universitygrid.260024.2, Downers Grove, Illinois, USA.
Chicago College of Pharmacy, Center of Pharmacometric Excellence, Midwestern Universitygrid.260024.2, Downers Grove, Illinois, USA.
College of Graduate Studies, Department of Pharmacology, Midwestern Universitygrid.260024.2, Downers Grove, Illinois, USA.
Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciencesgrid.413555.3, Albany, New York, USA.
Victorian Infectious Diseases Service, Peter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital, Melbourne, Australia.
Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
Menzies School of Health Researchgrid.271089.5, Charles Darwin University, Darwin, Australia.
Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland, USA.
Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Duke Universitygrid.26009.3d School of Medicine, Durham, North Carolina, USA.
Duke Clinical Research Institute, Durham, North Carolina, USA.
Antiviral Pharmacology Laboratory, University of Nebraska Medical Center (UNMC) Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
University of Nebraska Medical Center, College of Pharmacy, Omaha, Nebraska, USA.

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin induced acute kidney injury (AKI). Data were analyzed from a rat model (n=48) and two prospective clinical studies [PROVIDE (n=263) and CAMERA2 (n=291)]. A logit-link model ...

中文翻译：

大鼠和男性，了解万古霉素药代动力学/毒效学关系的转化模型。

已知万古霉素浓度曲线下面积 (AUC) 可预测万古霉素诱导的急性肾损伤 (AKI)。数据分析来自大鼠模型 (n=48) 和两项前瞻性临床研究 [PROVIDE (n=263) 和 CAMERA2 (n=291)]。一个logit-link模型...

更新日期：2021-09-12

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