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Peripheral Nerve Regeneration Using Different Germ Layer-Derived Adult Stem Cells in the Past Decade
Behavioural Neurology ( IF 2.8 ) Pub Date : 2021-09-10 , DOI: 10.1155/2021/5586523
Yu Li 1, 2 , Yuzuru Kamei 1 , Miki Kambe 1 , Katsumi Ebisawa 1 , Mayumi Oishi 1 , Keisuke Takanari 2
Affiliation  

Peripheral nerve injuries (PNIs) are some of the most common types of traumatic lesions affecting the nervous system. Although the peripheral nervous system has a higher regenerative ability than the central nervous system, delayed treatment is associated with disturbances in both distal sensory and functional abilities. Over the past decades, adult stem cell-based therapies for peripheral nerve injuries have drawn attention from researchers. This is because various stem cells can promote regeneration after peripheral nerve injuries by differentiating into neural-line cells, secreting various neurotrophic factors, and regulating the activity of in situ Schwann cells (SCs). This article reviewed research from the past 10 years on the role of stem cells in the repair of PNIs. We concluded that adult stem cell-based therapies promote the regeneration of PNI in various ways.

中文翻译:

在过去十年中使用不同胚层衍生的成体干细胞进行外周神经再生

周围神经损伤 (PNI) 是影响神经系统的一些最常见的创伤性病变类型。尽管周围神经系统的再生能力高于中枢神经系统,但延迟治疗会导致远端感觉和功能障碍。在过去的几十年里,基于成人干细胞的周围神经损伤疗法引起了研究人员的关注。这是因为各种干细胞可以通过分化为神经系细胞、分泌各种神经营养因子、调节原位神经元的活性,促进周围神经损伤后的再生施万细胞 (SC)。本文回顾了过去 10 年来关于干细胞在 PNI 修复中的作用的研究。我们得出结论,基于成人干细胞的疗法以多种方式促进 PNI 的再生。
更新日期:2021-09-10
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