For most cancers, multimodal cancer synergistic therapy is far more effective than monotherapy. Herein, a multifunctional nanocarrier based on lentinan (LTN) in situ functionalized molybdenum disulfide nanoflowers (MoS₂@LTN NFs) is developed by a simple hydrothermal method together with the in situ surface modification strategy. We utilized them to load chemotherapeutic drug gemcitabine (GEM) for in vitro and in vivo chemo-photothermal (Chemo-PTT) therapy. The results show that MoS₂@LTN NFs have the following characteristics: (1) the in situ encapsulated LTN can affect the crystal structure of MoS₂, and the light absorption capacity of MoS₂@LTN is 1.26 times higher than that of pure MoS₂; (2) it could achieve different drug release behaviors by dual stimulation with acidic pH and NIR laser irradiation; (3) in vivo experiments demonstrated that synergistic Chemo-PTT therapy achieved by using MoS₂@LTN-GEM has a more favorable therapeutic effect than monotherapy. Accordingly, MoS₂@LTN NFs could be developed as promising nanocarriers for synergistic therapy.

中文翻译：

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MoS2@lentinan 一步原位生长作为双刺激响应纳米载体用于协同化学光热疗法

对于大多数癌症，多模式癌症协同治疗远比单一治疗有效。在这里，基于香菇多糖（LTN）原位功能化二硫化钼纳米花（MoS ₂ @LTN NFs）的多功能纳米载体是通过简单的水热法和原位表面改性策略开发的。我们利用它们来加载用于体外和体内化学光热 (Chemo-PTT) 治疗的化疗药物吉西他滨 (GEM) 。结果表明MoS ₂ @LTN NFs具有以下特点：（1）原位封装的LTN会影响MoS ₂的晶体结构，MoS ₂ @LTN的光吸收能力比纯MoS ₂高1.26倍；(2)通过酸性pH和NIR激光照射的双重刺激可以实现不同的药物释放行为；(3)体内实验表明，使用MoS ₂ @LTN-GEM实现的协同Chemo-PTT疗法比单一疗法具有更有利的治疗效果。因此，MoS ₂ @LTN NFs 可以开发为有前景的纳米载体，用于协同治疗。