An in-hospital rapid method for quantifying the serum level of favipiravir (FPV) in the pharmacological treatment of COVID-19 was developed by an appropriate combination of a solid-phase extraction treatment and a reversed-phase HPLC/UV detection system. The quantification method was well-validated and applied to measuring the serum FPV level in a clinical practice at a general hospital that accepts COVID-19 patients. Furthermore, an analysis of data from our preliminary interaction analysis revealed, for the first time, that FPV selectively forms complexes with ferric (Fe³⁺) and cupric (Cu²⁺) ions.

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中文翻译：

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COVID-19药物治疗中法匹拉韦血清水平院内快速定量分析程序的优化

通过适当结合固相萃取处理和反相 HPLC/UV 检测系统，开发了一种在 COVID-19 药物治疗中量化法匹拉韦 (FPV) 血清水平的院内快速方法。该量化方法得到了充分验证，并应用于在接受 COVID-19 患者的综合医院的临床实践中测量血清 FPV 水平。此外，对我们初步相互作用分析的数据进行的分析首次表明，FPV 选择性地与三价铁 (Fe ³⁺ ) 和二价铜 (Cu ²⁺ ) 离子形成络合物。

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