Due to their global distribution, persistence, bioaccumulative potential and toxicity, perfluoroalkyl substances (PFASs) are considered as hazardous chemicals. Although many studies on PFASs pollution in aquatic environments have been done in the Northern hemisphere, less is known on PFASs pollution in African aquatic ecosystems and the risks they pose to humans through consumption of contaminated biota. The objective of this study was to determine the spatial distribution of PFASs in water, sediment, and fish tissue in Lake Hawassa, Ethiopia, and to investigate possible human health risks due to fish consumption. Among the PFASs detected in water and sediment, perfluorooctanoic acid (PFOA) was the most abundant with mean concentrations of 6.93 ng/L and 0.23 ng/g dw respectively. Long-chained PFASs dominated the PFAS accumulation profiles in fish tissues, with higher concentrations measured in liver compared to muscle tissue. The detected concentrations of PFASs were, however, often similar to those reported in other African aquatic ecosystems. This study showed no potential health risk due to consumption of contaminated fish based on mean concentrations and fish consumption. However, it is expected that peoples who consume more fish (fishermen and local peoples living close to Lake Hawassa) may suffer health risks due to PFASs contamination.

由于其全球分布、持久性、生物累积潜力和毒性，全氟烷基物质 (PFAS) 被视为危险化学品。尽管在北半球已经对水环境中的 PFASs 污染进行了许多研究，但对非洲水生生态系统中的 PFASs 污染以及它们通过食用受污染的生物群对人类构成的风险知之甚少。本研究的目的是确定埃塞俄比亚哈瓦萨湖水、沉积物和鱼类组织中 PFAS 的空间分布，并调查食用鱼类可能导致的人类健康风险。在水和沉积物中检测到的 PFAS 中，全氟辛酸 (PFOA) 含量最多，平均浓度分别为 6.93 ng/L 和 0.23 ng/g dw。长链 PFAS 主导了鱼类组织中的 PFAS 积累曲线，与肌肉组织相比，在肝脏中测量的浓度更高。然而，检测到的 PFAS 浓度通常与其他非洲水生生态系统中报告的浓度相似。这项研究表明，根据平均浓度和鱼类消费量，食用受污染的鱼不会造成潜在的健康风险。然而，预计食用更多鱼类的人（渔民和居住在哈瓦萨湖附近的当地人）可能会因 PFAS 污染而遭受健康风险。这项研究表明，根据平均浓度和鱼类消费量，食用受污染的鱼不会造成潜在的健康风险。然而，预计食用更多鱼类的人（渔民和居住在哈瓦萨湖附近的当地人）可能会因 PFAS 污染而遭受健康风险。这项研究表明，根据平均浓度和鱼类消费量，食用受污染的鱼不会造成潜在的健康风险。然而，预计食用更多鱼类的人（渔民和居住在哈瓦萨湖附近的当地人）可能会因 PFAS 污染而遭受健康风险。