Environmental Pollution ( IF 8.9 ) Pub Date : 2021-09-10 , DOI: 10.1016/j.envpol.2021.118140 Andrea Polachova 1 , Tomas Gramblicka 1 , Kamila Bechynska 1 , Ondrej Parizek 1 , Denisa Parizkova 1 , Darina Dvorakova 1 , Katerina Honkova 2 , Andrea Rossnerova 2 , Pavel Rossner 3 , Radim J Sram 2 , Jan Topinka 2 , Jana Pulkrabova 1
In this biomonitoring study, we evaluated the concentrations of 8 polychlorinated biphenyls (PCBs), 11 organochlorinated pesticides (OCPs), 33 brominated flame retardants (BFRs), 7 novel brominated and chlorinated flame retardants (novel FRs) and 30 per- and polyfluoroalkylated substances (PFAS) in human serum samples (n = 274). A total of 89 persistent organic pollutants (POPs) were measured in blood serum samples of city policemen living in three large cities and their adjacent areas (Ostrava, Prague, and Ceske Budejovice) in the Czech Republic. All samples were collected during the year 2019 in two sampling periods (spring and autumn). The identification/quantification of PCBs, OCPs, BFRs, novel FRs and PFAS was performed by means of gas chromatography coupled to (tandem) mass spectrometry (GC–MS/(MS)) and ultra-high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry (UHPLC–MS/MS). The most frequently detected pollutants were perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHxS), 2,2′,3,4,4′,5′-hexachlorobiphenyl (CB 138), 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB 153), 2,2′,3,3′,4,4′,5-heptachlorobiphenyl (CB 170), 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (CB 180), hexachlorobenzene (HCB), and p,p'-dichlorodiphenyldichloroethylene (p,p′-DDE) quantified in 100% of serum samples. In the serum samples, the concentrations of determined POPs were in the range of 0.108–900 ng g−1 lipid weight (lw) for PCBs, 0.106–1016 ng g−1 lw for OCPs, <0.1–618 ng g−1 lw for FRs and <0.01–18.3 ng mL−1 for PFAS, respectively. Locality, sampling season, and age were significantly associated with several POP concentrations. One of the important conclusions was that within the spring sampling period, statistically significant higher concentrations of CB 170 and CB 180 were observed in the samples from Ostrava (industrial area) compared to Prague and Ceske Budejovice. Older policemen had higher concentrations of five PCBs and two OCPs in blood serum.
中文翻译:
捷克城市警察血清样本中 89 种持久性有机污染物的生物监测
在这项生物监测研究中,我们评估了 8 种多氯联苯 (PCB)、11 种有机氯化农药 (OCP)、33 种溴化阻燃剂 (BFR)、7 种新型溴化和氯化阻燃剂(新型 FR)以及 30 种全氟和多氟烷基化物质的浓度(PFAS) 在人血清样本中 (n = 274)。在居住在捷克共和国三个大城市及其邻近地区(俄斯特拉发、布拉格和捷克布杰约维采)的城市警察的血清样本中,共测定了 89 种持久性有机污染物 (POPs)。所有样本均于 2019 年在两个采样期(春季和秋季)收集。PCB、OCP、BFR、通过气相色谱与(串联)质谱联用(GC-MS/(MS))和超高效液相色谱与三重四极杆串联质谱联用(UHPLC-MS/MS)进行新型 FR 和 PFAS。最常检测到的污染物是全氟辛酸 (PFOA)、全氟壬酸 (PFNA)、全氟癸酸 (PFDA)、全氟辛烷磺酸 (PFOS)、全氟己烷磺酸 (PFHxS)、2,2',3,4,4',5'-六氯联苯(CB 138), 2,2',4,4',5,5'-六氯联苯 (CB 153), 2,2',3,3',4,4',5-七氯联苯 (CB 170), 2 ,2',3,4,4',5,5'-七氯联苯 (CB 180)、六氯苯 (HCB) 和p,p' -二氯二苯基二氯乙烯 ( p,p' -DDE) 在 100% 的血清样品中定量。在血清样品中,测定的持久性有机污染物的浓度范围为 0.108–900 ng g -1脂重 (lw)(PCBs),0.106–1016 ng g -1 lw(OCPs),<0.1–618 ng g -1 lw对于 FR 和 <0.01–18.3 ng mL -1分别用于 PFAS。地点、采样季节和年龄与几种持久性有机污染物浓度显着相关。重要结论之一是,在春季采样期间,与布拉格和捷克布杰约维采相比,俄斯特拉发(工业区)的样品中观察到的 CB 170 和 CB 180 浓度具有统计学意义。年长的警察血清中五种多氯联苯和两种 OCP 的浓度较高。