Pelvic organ prolapse (POP) is a frequent chronic illness, which severely affects women's quality of life. In this work, four composite electrospun scaffold were developed for POP using decellularized amniotic matrix (dHAM) and biocompatible polymers like poly(ε-caprolactone) (PCL) and poly(lactide-co-glycolide) polymers (PLGA). Tests to assess the physicochemical characterizations of the novel scaffold were performed. The results showed that scaffolds had good hydrophilicity, suitable degradation time and mechanical properties for pelvic floor regeneration. Cell tests with human umbilical cord mesenchymal stem cells (hUC-MSCs) showed that scaffolds were non-cytotoxic. In conclusion, composite electrospun scaffold containing dHAM showed promising potential for POP.

盆腔器官脱垂（POP）是一种常见的慢性疾病，严重影响女性的生活质量。在这项工作中，使用脱细胞羊膜基质 (dHAM) 和生物相容性聚合物如聚 (ε-己内酯) (PCL) 和聚 (丙交酯-共-乙交酯) 聚合物 (PLGA)，为 POP 开发了四种复合电纺支架。进行了评估新型支架的物理化学特性的测试。结果表明，支架具有良好的亲水性、合适的降解时间和骨盆底再生的力学性能。用人脐带间充质干细胞 (hUC-MSC) 进行的细胞测试表明，支架是无细胞毒性的。总之，含有 dHAM 的复合电纺支架显示出有希望的 POP 潜力。