Abstract

Acute toxicity of nanoparticles of aluminum oxide (Al₂O₃) with a size of 13–16 nm was investigated by the biotesting method using Paramecium caudatum ciliates in the concentration range of 10–100 μg/mL. Aluminum oxide has an acute toxic effect on paramecium at concentrations of 20–100 μg/mL. The mean lethal dose (LD₅₀) is equal to the concentration of nanoparticles at which the mortality of ciliates in relation to the control reached 50%. The LD₅₀ for Al₂O₃ nanoparticles is 23 μg/mL at a 24-h exposure. According to published data, the toxic effect of Al₂O₃ nanoparticles is specific and depends on the size and surface charge of the particles and on the interfacial interaction of nanoparticles with the cell surface, as well as on the concentration and exposure time.

中文翻译：

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Infusoria Paramecium caudatum 在氧化铝纳米颗粒存在下的存活

摘要

尺寸为 13-16 nm的氧化铝 (Al ₂ O ₃ )纳米粒子的急性毒性通过使用浓度范围为 10-100 μg/mL 的草履虫纤毛虫的生物测试方法进行了研究。浓度为 20–100 μg/mL 的氧化铝对草履虫具有急性毒性作用。平均致死剂量 (LD ₅₀ ) 等于纤毛虫相对于对照组的死亡率达到 50% 时的纳米颗粒浓度。Al ₂ O ₃纳米颗粒的LD ₅₀在24 小时暴露时为23 μg/mL。根据公开资料，Al ₂ O ₃的毒性作用 纳米颗粒是特定的，取决于颗粒的大小和表面电荷，以及纳米颗粒与细胞表面的界面相互作用，以及浓度和暴露时间。