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Nanoformulations of Drugs Based on Biodegradable Lactide Copolymers with Various Molecular Structures and Architectures
Nanotechnologies in Russia Pub Date : 2021-09-10 , DOI: 10.1134/s2635167621040121
N. G. Sedush 1 , Y. A. Kadina 1 , E. V. Razuvaeva 1 , A. A. Puchkov 1 , E. M. Shirokova 1 , V. I. Gomzyak 1 , K. T. Kalinin 1 , A. I. Kulebyakina 1 , S. N. Chvalun 1
Affiliation  

Abstract

Modern pharmaceutics are actively developing towards the design of targeted drugs. The development of selectively acting formulations requires the creation of smart delivery systems based on carriers that would first find the target cells and enter them and then release the active substance locally. Nanoparticles of biocompatible and biodegradable polymers can be effectively used as such carriers. Flexible regulation of the molecular structure and architecture of polymers, as well as the modification of nanoparticles with vector molecules, allows one to construct carrier particles for the development of nanoformulations for active agents of various nature. This review presents the main approaches to the design of nanoformulations for targeted delivery, describes the methods for the preparation and study of nanoparticles based on hydrophobic and amphiphilic biodegradable lactide polymers, and discusses the effect of the molecular structure and preparation conditions on the characteristics of nanoparticles in detail. Some results of research in this area of the Kurchatov complex of NBIСS nature-like technologies are also presented.



中文翻译:

基于具有各种分子结构和结构的可生物降解的丙交酯共聚物的药物纳米制剂

摘要

现代药剂学正朝着靶向药物的设计方向积极发展。选择性作用配方的开发需要创建基于载体的智能递送系统,该系统将首先找到靶细胞并进入它们,然后在局部释放活性物质。生物相容性和可生物降解聚合物的纳米颗粒可以有效地用作此类载体。灵活调节聚合物的分子结构和结构,以及用载体分子修饰纳米颗粒,可以构建载体颗粒,用于开发各种性质的活性剂的纳米制剂。本综述介绍了设计用于靶向递送的纳米制剂的主要方法,描述了基于疏水性和两性可生物降解丙交酯聚合物的纳米粒子的制备和研究方法,并详细讨论了分子结构和制备条件对纳米粒子特性的影响。还介绍了 NBIСS 类自然技术库尔恰托夫复合体在这方面的一些研究结果。

更新日期:2021-09-10
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