Clearance of dMiro from the outer mitochondrial membrane is a prerequisite for mitophagy of dysfunctional mitochondria. Li et al. find that oxidative stress stabilizes dMiro via its interaction with dMIC60. Dissociating this complex by genetic or pharmacologic interventions counteracts neurological aging in flies.

中文翻译：

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MIC60 中继氧化以阻止线粒体自噬

从线粒体外膜清除 dMiro 是功能失调的线粒体线粒体自噬的先决条件。李等人。发现氧化应激通过与 dMIC60 的相互作用稳定 dMiro。通过遗传或药物干预分离这种复合物可以抵消果蝇的神经衰老。