ABSTRACT

Background: ¹⁸F-fluorodeoxyglucose positron-emitted tomography (FDG-PET) is a promising yet unexplored functional neuroimaging tool in the study and prognosis of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest or respiratory failure. The present study aimed to correlate clinical data and FDG-PET scans for both analysis and prognostic use. Methods: 24 patients from an intensive rehabilitation ward were retrospectively evaluated. Data collected included age, gender, cause of anoxic event, length of stay in acute and rehabilitation units, discharge destination, and evaluation at admission and discharge using three clinical scales to assess cognitive function, independence and disability. Subjects were identified as good and bad performers on the basis of quantitative analysis of FDG-PET scans with the Cortex ID software. The relation between glucose uptake reduction and neurological outcome was evaluated. Results: good and bad performers presented no statistically significant difference regarding demographical data and in-hospital length of stay. The two categories significantly differed for impairment and disability levels both at admission and at discharge from the inpatient rehabilitation unit. Conclusions: FDG-PET considerably facilitates the early identification of patients with HIE who will have poor neurological outcome and could inform planning for their rehabilitation and care.

摘要

背景： ¹⁸ F-氟脱氧葡萄糖正电子发射断层扫描 (FDG-PET) 是一种有前途但尚未探索的功能性神经影像学工具，可用于心脏骤停或呼吸衰竭后缺氧缺血性脑病 (HIE) 的研究和预后。本研究旨在将临床数据和 FDG-PET 扫描相关联，以用于分析和预后用途。方法：来自强化康复病房的 24 名患者接受了回顾性评估。收集的数据包括年龄、性别、缺氧事件的原因、在急诊和康复病房的停留时间、出院目的地以及入院和出院时的评估，使用三种临床量表来评估认知功能、独立性和残疾。基于使用 Cortex ID 软件对 FDG-PET 扫描进行定量分析，将受试者确定为表现好的和差的。评估葡萄糖摄取减少与神经学结果之间的关系。结果：表现好和差的人在人口统计数据和住院时间方面没有统计学上的显着差异。这两个类别在住院康复病房入院和出院时的损伤和残疾水平显着不同。结论：FDG-PET 极大地促进了早期识别神经功能不良的 HIE 患者，并可以为他们的康复和护理计划提供信息。