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Potential Significance and Clinical Value Explorations of Calmin (CLMN) in Breast Invasive Carcinoma
International Journal of General Medicine ( IF 2.3 ) Pub Date : 2021-09-10 , DOI: 10.2147/ijgm.s326960 Yan Wu 1 , Chun-Ping Liu 2 , Cheng Xiang 3 , Kai-Fang Xiang 4
International Journal of General Medicine ( IF 2.3 ) Pub Date : 2021-09-10 , DOI: 10.2147/ijgm.s326960 Yan Wu 1 , Chun-Ping Liu 2 , Cheng Xiang 3 , Kai-Fang Xiang 4
Affiliation
Objective: Function of calmin (CLMN) was rarely reported in human diseases, especially in tumor. Present study initially assessed the significance of CLMN in breast invasive carcinoma (BRCA).
Methods: Expressions of CLMN containing mRNA and protein in BRCA was firstly assessed, and association of CLMN mRNA expression with clinical phenotypes of BRCA patients was analyzed as well. Prognostic value of CLMN in BRCA was subsequently predicted based on the clinical characteristics of patients. Finally, the potential biological function associated with CLMN involved in BRCA was revealed.
Results: (1) The mRNA expression of CLMN was lower in BRCA compared with that in normal patients (P< 0.001). However, result of CLMN total protein expression was opposite (P< 0.05). (2) The mRNA expression of CLMN was statistically associated with BRCA patient’s age, gender, PR status, ER status, histological type, tumor stage, copy number, and methylation level (all P< 0.05). (3) Compared with low expression group, high expression of CLMN was conducive to the overall survival of BRCA patients (P=0.0011). Detailed, survival difference between CLMN high and low expression groups was observed in patients with stage 1 (P=0.0250), positive ER status (P=0.0042), negative HER status (P=0.0433), luminal A (P=0.0065), luminal B (P=0.0123) and positive lymph node status (P=0.0069). Pathway analysis suggested that CLMN mainly participated in cell cycle process (P< 0.05) and exerted inhibition effect on the cell cycle involved in BRCA (P< 0.05).
Conclusion: CLMN mRNA high expression prolonged the survival time of patients and caused a favorable prognosis. The positive function of CLMN in BRCA required further investigation in future work.
Keywords: CLMN, breast invasive carcinoma, prognosis, pathway, cell cycle
中文翻译：
Calmin（CLMN）在乳腺浸润癌中的潜在意义和临床价值探索
目的：钙蛋白（CLMN）在人类疾病中的作用鲜有报道，尤其是在肿瘤中。本研究初步评估了 CLMN 在乳腺浸润癌 (BRCA) 中的意义。
方法：首先评估BRCA中CLMN mRNA和蛋白的表达，并分析CLMN mRNA表达与BRCA患者临床表型的关系。随后根据患者的临床特征预测 CLMN 在 BRCA 中的预后价值。最后，揭示了与 BRCA 相关的 CLMN 的潜在生物学功能。
结果：（1）BRCA中CLMN mRNA表达低于正常患者（P< 0.001)。CLMN总蛋白表达结果相反（P <0.05）。(2)CLMN mRNA表达与BRCA患者的年龄、性别、PR状态、ER状态、组织学类型、肿瘤分期、拷贝数、甲基化水平有统计学相关性(均P < 0.05)。(3)与低表达组相比，CLMN高表达有利于BRCA患者的总体生存( P =0.0011)。详细，CLMN高表达组和低表达组之间的生存差异在1期（P = 0.0250）、ER阳性（P = 0.0042）、HER阴性（P = 0.0433）、luminal A（P = 0.0065）、管腔 B ( P= 0.0123）和阳性淋巴结状态（P = 0.0069）。通路分析表明，CLMN主要参与细胞周期过程（P < 0.05），对参与BRCA的细胞周期发挥抑制作用（P < 0.05）。
结论： CLMN mRNA高表达延长了患者的生存时间，预后良好。CLMN 在 BRCA 中的积极作用需要在未来的工作中进一步研究。
关键词： CLMN，乳腺浸润癌，预后，通路，细胞周期
更新日期：2021-09-10
Methods: Expressions of CLMN containing mRNA and protein in BRCA was firstly assessed, and association of CLMN mRNA expression with clinical phenotypes of BRCA patients was analyzed as well. Prognostic value of CLMN in BRCA was subsequently predicted based on the clinical characteristics of patients. Finally, the potential biological function associated with CLMN involved in BRCA was revealed.
Results: (1) The mRNA expression of CLMN was lower in BRCA compared with that in normal patients (P< 0.001). However, result of CLMN total protein expression was opposite (P< 0.05). (2) The mRNA expression of CLMN was statistically associated with BRCA patient’s age, gender, PR status, ER status, histological type, tumor stage, copy number, and methylation level (all P< 0.05). (3) Compared with low expression group, high expression of CLMN was conducive to the overall survival of BRCA patients (P=0.0011). Detailed, survival difference between CLMN high and low expression groups was observed in patients with stage 1 (P=0.0250), positive ER status (P=0.0042), negative HER status (P=0.0433), luminal A (P=0.0065), luminal B (P=0.0123) and positive lymph node status (P=0.0069). Pathway analysis suggested that CLMN mainly participated in cell cycle process (P< 0.05) and exerted inhibition effect on the cell cycle involved in BRCA (P< 0.05).
Conclusion: CLMN mRNA high expression prolonged the survival time of patients and caused a favorable prognosis. The positive function of CLMN in BRCA required further investigation in future work.
Keywords: CLMN, breast invasive carcinoma, prognosis, pathway, cell cycle
中文翻译：
Calmin（CLMN）在乳腺浸润癌中的潜在意义和临床价值探索
目的：钙蛋白（CLMN）在人类疾病中的作用鲜有报道，尤其是在肿瘤中。本研究初步评估了 CLMN 在乳腺浸润癌 (BRCA) 中的意义。
方法：首先评估BRCA中CLMN mRNA和蛋白的表达，并分析CLMN mRNA表达与BRCA患者临床表型的关系。随后根据患者的临床特征预测 CLMN 在 BRCA 中的预后价值。最后，揭示了与 BRCA 相关的 CLMN 的潜在生物学功能。
结果：（1）BRCA中CLMN mRNA表达低于正常患者（P< 0.001)。CLMN总蛋白表达结果相反（P <0.05）。(2)CLMN mRNA表达与BRCA患者的年龄、性别、PR状态、ER状态、组织学类型、肿瘤分期、拷贝数、甲基化水平有统计学相关性(均P < 0.05)。(3)与低表达组相比，CLMN高表达有利于BRCA患者的总体生存( P =0.0011)。详细，CLMN高表达组和低表达组之间的生存差异在1期（P = 0.0250）、ER阳性（P = 0.0042）、HER阴性（P = 0.0433）、luminal A（P = 0.0065）、管腔 B ( P= 0.0123）和阳性淋巴结状态（P = 0.0069）。通路分析表明，CLMN主要参与细胞周期过程（P < 0.05），对参与BRCA的细胞周期发挥抑制作用（P < 0.05）。
结论： CLMN mRNA高表达延长了患者的生存时间，预后良好。CLMN 在 BRCA 中的积极作用需要在未来的工作中进一步研究。
关键词： CLMN，乳腺浸润癌，预后，通路，细胞周期
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