The upper respiratory tract is the major entry site for Streptococcus pyogenes and influenza virus. Vaccine strategies that activate mucosal immunity could significantly reduce morbidity and mortality because of these pathogens. The severity of influenza is significantly greater if a streptococcal infection occurs during the viraemic period and generally viral infections complicated by a subsequent bacterial infection are known as super-infections. We describe an innovative vaccine strategy against influenza virus:S. pyogenes super-infection. Moreover, we provide the first description of a liposomal multi-pathogen-based platform that enables the incorporation of both viral and bacterial antigens into a vaccine and constitutes a transformative development.

中文翻译：

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组合脂质体肽疫苗可诱导 IgA 并提供针对流感病毒和细菌重复感染的保护

上呼吸道是化脓性链球菌和流感病毒的主要进入部位。由于这些病原体，激活粘膜免疫的疫苗策略可以显着降低发病率和死亡率。如果在病毒血症期间发生链球菌感染，流感的严重程度会显着增加，通常病毒感染并发随后的细菌感染被称为超级感染。我们描述了一种针对流感病毒的创新疫苗策略：S。 化脓性超级感染。此外，我们首次描述了基于脂质体的多病原体平台，该平台能够将病毒和细菌抗原结合到疫苗中并构成变革性发展。