Due to their prominent physicochemical properties, 2D materials are broadly applied in biomedicine. Currently, 2D materials have achieved great success in treating many diseases such as cancer and tissue engineering as well as bone therapy. Based on their different characteristics, 2D materials could function in various ways in different bone diseases. Herein, the application of 2D materials in bone tissue engineering, joint lubrication, infection of orthopedic implants, bone tumors, and osteoarthritis are firstly reviewed comprehensively together. Meanwhile, different mechanisms by which 2D materials function in each disease reviewed below are also reviewed in detail, which in turn reveals the versatile functions and application of 2D materials. At last, the outlook on how to further broaden applications of 2D materials in bone therapies based on their excellent properties is also discussed.

由于其突出的物理化学性质，二维材料被广泛应用于生物医学领域。目前，二维材料在治疗癌症和组织工程以及骨治疗等多种疾病方面取得了巨大成功。基于它们的不同特性，二维材料可以在不同的骨骼疾病中以多种方式发挥作用。本文首先对二维材料在骨组织工程、关节润滑、骨科植入物感染、骨肿瘤、骨关节炎等方面的应用进行全面综述。同时，还详细回顾了二维材料在以下所回顾的每种疾病中发挥作用的不同机制，从而揭示了二维材料的多功能功能和应用。最后，