Breast cancer has become the most commonly diagnosed cancer type in the world. A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for breast cancer therapy. However, the intricacy of precise delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle. Therefore, to ensure that the therapeutic agents are synchronously delivered to the tumor site for their synergistic effect, a multifunctional nanoparticle system (PCRHNs) is developed, which is grafted onto the prussian blue nanoparticles (PB NPs) by reduction-responsive camptothecin (CPT) prodrug copolymer, and then modified with tumor-targeting peptide cyclo(Asp-d-Phe-Lys-Arg-Gly) (cRGD) and hyaluronic acid (HA). PCRHNs exhibited nano-sized structure with good monodispersity, high load efficiency of CPT, triggered CPT release in response to reduction environment, and excellent photothermal conversion under laser irradiation. Furthermore, PCRHNs can act as a photoacoustic imaging contrast agent-guided PTT. In vivo studies indicate that PCRHNs exhibited excellent biocompatibility, prolonged blood circulation, enhanced tumor accumulation, allow tumor-specific chemo-photothermal therapy to achieve synergistic antitumor effects with reduced systemic toxicity. Moreover, hyperthermia-induced upregulation of heat shock protein 70 in the tumor cells could be inhibited by CPT. Collectively, PCRHNs may be a promising therapeutic way for breast cancer therapy.

乳腺癌已成为世界上最常见的癌症类型。化学疗法和光热疗法 (PTT) 的组合已成为乳腺癌治疗的一种有前途的策略。然而，精确递送的复杂性和在特定肿瘤部位启动药物释放的能力仍然是一个具有挑战性的难题。因此，为确保治疗剂同步递送至肿瘤部位以发挥协同作用，开发了一种多功能纳米粒子系统（PCRHNs），该系统通过还原响应喜树碱（CPT）接枝到普鲁士蓝纳米粒子（PB NPs）上。前药共聚物，然后用肿瘤靶向肽环（Asp- d-Phe-Lys-Arg-Gly) (cRGD) 和透明质酸 (HA)。PCRHNs具有纳米级结构，具有良好的单分散性、高CPT负载效率、响应还原环境触发CPT释放以及在激光照射下具有优异的光热转换。此外，PCRHN 可以作为光声成像造影剂引导的 PTT。体内研究表明，PCRHNs表现出优异的生物相容性，延长血液循环，增强肿瘤积累，使肿瘤特异性化学-光热疗法能够实现协同抗肿瘤作用，同时降低全身毒性。此外，CPT 可以抑制高温诱导的肿瘤细胞中热休克蛋白 70 的上调。总的来说，PCRHNs 可能是一种有前途的乳腺癌治疗方法。