RNA-binding proteins (RBPs) are critical players in the post-transcriptional regulation of gene expression and are associated with each event in RNA metabolism. The term ‘RNA-binding motif’ (RBM) is assigned to novel RBPs with one or more RNA recognition motif (RRM) domains that are mainly involved in the nuclear processing of RNAs. RBM47 is a novel RBP conserved in vertebrates with three RRM domains whose contributions to various aspects of cellular functions are as yet emerging. Loss of RBM47 function affects head morphogenesis in zebrafish embryos and leads to perinatal lethality in mouse embryos, thereby assigning it to be an essential gene in early development of vertebrates. Its function as an essential cofactor for APOBEC1 in C to U RNA editing of several targets through substitution for A1CF in the A1CF-APOBEC1 editosome, established a new paradigm in the field. Recent advances in the understanding of its involvement in cancer progression assigned RBM47 to be a tumor suppressor that acts by inhibiting EMT and Wnt/\(\upbeta\)-catenin signaling through post-transcriptional regulation. RBM47 is also required to maintain immune homeostasis, which adds another facet to its regulatory role in cellular functions. Here, we review the emerging roles of RBM47 in various biological contexts and discuss the current gaps in our knowledge alongside future perspectives for the field.

RNA 结合蛋白 (RBP) 是基因表达转录后调控的关键参与者，并且与 RNA 代谢中的每个事件相关。术语“RNA 结合基序”(RBM) 指具有一个或多个主要参与 RNA 核加工的 RNA 识别基序 (RRM) 结构域的新型 RBP。RBM47 是一种在脊椎动物中保守的新型 RBP，具有三个 RRM 结构域，其对细胞功能各个方面的贡献尚未出现。RBM47 功能的丧失会影响斑马鱼胚胎的头部形态发生，并导致小鼠胚胎的围产期致死率，从而使其成为脊椎动物早期发育的必需基因。它通过替代 A1CF-APOBEC1 编辑体中的 A1CF，作为 APOBEC1 在 C 到 U RNA 编辑几个靶标中的重要辅助因子，开创了该领域的新范式。对其参与癌症进展的理解的最新进展将 RBM47 指定为通过抑制 EMT 和 Wnt/ 发挥作用的肿瘤抑制因子。\(\upbeta\) -catenin信号通过转录后调控。RBM47 也是维持免疫稳态所必需的，这为其在细胞功能中的调节作用增加了另一个方面。在这里，我们回顾了 RBM47 在各种生物学背景下的新兴作用，并讨论了我们目前的知识差距以及该领域的未来前景。