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The Effect of Familiarity on Neural Representations of Music and Language.
Journal of Cognitive Neuroscience ( IF 3.2 ) Pub Date : 2021-07-01 , DOI: 10.1162/jocn_a_01737
Avital Sternin 1 , Lucy M McGarry 1 , Adrian M Owen 1 , Jessica A Grahn 1
Affiliation  

We investigated how familiarity alters music and language processing in the brain. We used fMRI to measure brain responses before and after participants were familiarized with novel music and language stimuli. To manipulate the presence of language and music in the stimuli, there were four conditions: (1) whole music (music and words together), (2) instrumental music (no words), (3) a capella music (sung words, no instruments), and (4) spoken words. To manipulate participants' familiarity with the stimuli, we used novel stimuli and a familiarization paradigm designed to mimic "natural" exposure, while controlling for autobiographical memory confounds. Participants completed two fMRI scans that were separated by a stimulus training period. Behaviorally, participants learned the stimuli over the training period. However, there were no significant neural differences between the familiar and unfamiliar stimuli in either univariate or multivariate analyses. There were differences in neural activity in frontal and temporal regions based on the presence of language in the stimuli, and these differences replicated across the two scanning sessions. These results indicate that the way we engage with music is important for creating a memory of that music, and these aspects, over and above familiarity on its own, may be responsible for the robust nature of musical memory in the presence of neurodegenerative disorders such as Alzheimer disease.

中文翻译:

熟悉度对音乐和语言的神经表征的影响。

我们调查了熟悉程度如何改变大脑中的音乐和语言处理。我们使用 fMRI 来测量参与者熟悉新音乐和语言刺激前后的大脑反应。为了操纵刺激中语言和音乐的存在,有四​​个条件:(1)整首音乐(音乐和词在一起),(2)器乐(无词),(3)无伴奏合唱(唱词,无乐器)和(4)口语。为了操纵参与者对刺激的熟悉程度,我们使用了新颖的刺激和旨在模仿“自然”暴露的熟悉范式,同时控制自传记忆混淆。参与者完成了两次 fMRI 扫描,这些扫描被一个刺激训练期分开。在行为上,参与者在训练期间学习了刺激。然而,在单变量或多变量分析中,熟悉和不熟悉的刺激之间没有显着的神经差异。根据刺激中语言的存在,额叶和颞区的神经活动存在差异,并且这些差异在两次扫描过程中重复出现。这些结果表明,我们接触音乐的方式对于创造对音乐的记忆很重要,而这些方面,除了熟悉本身之外,可能是在神经退行性疾病(如阿尔茨海默病。根据刺激中语言的存在,额叶和颞区的神经活动存在差异,并且这些差异在两次扫描过程中重复出现。这些结果表明,我们接触音乐的方式对于创造对音乐的记忆很重要,而这些方面,除了熟悉本身之外,可能是在神经退行性疾病(如阿尔茨海默病。根据刺激中语言的存在,额叶和颞区的神经活动存在差异,并且这些差异在两次扫描过程中重复出现。这些结果表明,我们接触音乐的方式对于创造对音乐的记忆很重要,而这些方面,除了熟悉本身之外,可能是在神经退行性疾病(如阿尔茨海默病。
更新日期:2021-07-01
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