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Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
PLOS Biology ( IF 9.8 ) Pub Date : 2021-09-08 , DOI: 10.1371/journal.pbio.3001353
Daniel Sauter 1 , Frank Kirchhoff 2
Affiliation  

Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.

中文翻译:

少即是多:CpG 二核苷酸的偏向损失可增强抗病毒免疫力。

病毒不仅会影响我们的日常生活,还会影响我们的基因组进化。最近的一项研究表明,锌指抗病毒蛋白 (ZAP) 以有偏见的方式驱动 CpG 抑制。参与防御病毒入侵者的基因特别受到 CpG 抑制,以避免自我靶向并促进有效的免疫反应。
更新日期:2021-09-08
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