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Dietary Naringenin Preserves Insulin Sensitivity and Grip Strength and Attenuates Inflammation but Accelerates Weight Loss in a Mouse Model of Cancer Cachexia
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2021-09-09 , DOI: 10.1002/mnfr.202100268
Deena B Snoke 1 , Yuko Nishikawa 2 , Rachel M Cole 1 , Ai Ni 3 , Austin Angelotti 1 , Yael Vodovotz 2 , Martha A Belury 4
Affiliation  

Cancer cachexia is characterized by the loss of skeletal muscle resulting in functional impairment, reduced quality of life and mortality. Naringenin, a flavonoid found in citrus fruits, improves insulin sensitivity and reduces inflammation and tumor growth in preclinical models. Therefore, the study hypothesizes that dietary supplementation of naringenin will improve insulin sensitivity, decrease inflammation, slow body weight loss, and delay tumor growth in a mouse model of cancer cachexia.

中文翻译:

膳食柚皮素可保持癌症恶病质小鼠模型的胰岛素敏感性和握力并减轻炎症,但加速减肥

癌症恶病质的特征是骨骼肌丧失,导致功能障碍、生活质量下降和死亡率下降。柚皮素是柑橘类水果中发现的一种黄酮类化合物,可在临床前模型中提高胰岛素敏感性并减少炎症和肿瘤生长。因此,该研究假设,在癌症恶病质小鼠模型中,膳食补充柚皮素将提高胰岛素敏感性、减少炎症、减缓体重减轻并延缓肿瘤生长。
更新日期:2021-09-09
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