Structured nanoassemblies are biomimetic structures that are enabling applications from nanomedicine to catalysis. One approach to achieve these spatially organized architectures is utilizing amphiphilic diblock copolymers with one or two macromolecular backbones that self-assemble in solution. To date, the impact of alternating backbone architectures on self-assembly and drug delivery is still an area of active research limited by the strategies used to synthesize these multiblock polymers. Here, we report self-assembling ABC-type alginate-based triblock copolymers with the backbones of three distinct biomaterials utilizing a facile conjugation approach. This “polymer mosaic” was synthesized by the covalent attachment of alginate with a PLA/PEG diblock copolymer. The combination of alginate, PEG, and PLA domains resulted in an amphiphilic copolymer that self-assembles into nanoparticles with a unique morphology of alginate domain compartmentalization. These particles serve as a versatile platform for co-encapsulation of hydrophilic and hydrophobic small molecules, their spatiotemporal release, and show potential as a drug delivery system for combination therapy.

中文翻译：

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基于藻酸盐的两亲嵌段共聚物作为药物协同递送平台

结构化纳米组件是仿生结构，可实现从纳米医学到催化的应用。实现这些空间组织结构的一种方法是利用具有一个或两个在溶液中自组装的大分子骨架的两亲二嵌段共聚物。迄今为止，交替主链结构对自组装和药物递送的影响仍然是一个活跃的研究领域，受到用于合成这些多嵌段聚合物的策略的限制。在这里，我们报告了自组装 ABC 型海藻酸盐基三嵌段共聚物，该共聚物具有三种不同生物材料的骨架，采用简便的共轭方法。这种“聚合物镶嵌”是通过藻酸盐与 PLA/PEG 二嵌段共聚物的共价连接合成的。海藻酸盐、PEG、和PLA结构域产生了一种两亲共聚物，该共聚物自组装成具有独特形态的藻酸盐结构域区室化的纳米颗粒。这些颗粒可作为一个多功能平台，用于共同封装亲水性和疏水性小分子、它们的时空释放，并显示出作为联合治疗药物输送系统的潜力。