Immunoglobulin A (IgA) nephropathy (Berger’s disease) is the most common glomerulonephritis worldwide. The disease typically is chronic and lifelong and eventually progresses to impaired renal function in a substantial proportion of cases. It has been known for some time that there is a correlation between IgA nephropathy and celiac disease, but until now it has remained unclear whether treatment of the underlying celiac disease has any meaningful impact on the progression of the renal disease. Therefore, until now, screening for celiac disease in patients presenting with IgA nephropathy has not been universally recommended in the absence of suggestive gastrointestinal symptoms. This report describes a case of IgA nephropathy in an adolescent boy that turned out to be the initial presentation of celiac disease. More importantly, it documents the complete laboratory normalization of his renal anomalies at 5-year follow-up after treatment of his celiac disease with implementation of a gluten-free diet. This case highlights the importance of awareness that suspected IgA nephropathy, even in the absence of gastrointestinal symptoms, should prompt screening for underlying celiac disease as a potential, and possibly treatable, cause.

免疫球蛋白 A (IgA) 肾病（伯杰氏病）是世界范围内最常见的肾小球肾炎。该疾病通常是慢性的和终生的，并且在相当大比例的病例中最终发展为肾功能受损。一段时间以来，人们已经知道 IgA 肾病与乳糜泻之间存在相关性，但直到现在仍不清楚基础乳糜泻的治疗是否对肾病的进展有任何有意义的影响。因此，到目前为止，在没有提示性胃肠道症状的情况下，尚未普遍推荐对 IgA 肾病患者进行乳糜泻筛查。本报告描述了一名青春期男孩的 IgA 肾病病例，该病例被证明是乳糜泻的最初表现。更重要的是，它记录了在实施无麸质饮食治疗乳糜泻后 5 年随访时，他的肾脏异常完全实验室正常化。该病例强调了意识到疑似 IgA 肾病的重要性，即使没有胃肠道症状，也应及时筛查潜在的乳糜泻，作为潜在的、可能可治疗的病因。