Abstract

A new cyclopentenone derivative, 4-hydroxyhypocrenone A, and a new naturally-occurring wickerol derivative, 8-acetoxywickerol A, as well as two known compounds, hypocrenone A and wickerol B, were purified from Trichoderma atroviride A-YMD-9-4, an endophytic fungus isolated from the marine red alga Gracilaria verrucosa. The structures and relative configurations of two new isolates were established by a combination of 1 D/2D NMR, IR, and mass spectroscopic methods, and the absolute configuration of 1 was assigned on the basis of ECD data analyzed by quantum chemical calculations. Compounds 1 and 2 exhibited weak inhibition of one or two marine phytoplankton species.

摘要

一种新的环戊烯酮衍生物 4-hydroxyhypocrenone A 和一种新的天然 wickerol 衍生物 8-acetoxywickerol A，以及两种已知的化合物 hypocrenone A 和 wickerol B，是从木霉 atroviride A-YMD-9-4 中纯化的，一种从海洋红藻Gracilaria verrucosa中分离出来的内生真菌。两种新分离物的结构和相对构型是通过一维/二维核磁共振、红外和质谱方法的组合确定的，并根据通过量子化学计算分析的 ECD 数据分配1的绝对构型。化合物1和2对一种或两种海洋浮游植物表现出较弱的抑制作用。