For many years, it was believed that the aging process was inevitable and that age-related diseases could not be prevented or reversed. The geroscience hypothesis, however, posits that aging is, in fact, malleable and, by targeting the hallmarks of biological aging, it is indeed possible to alleviate age-related diseases and dysfunction and extend longevity. This field of geroscience thus aims to prevent the development of multiple disorders with age, thereby extending healthspan, with the reduction of morbidity toward the end of life. Experts in the field have made remarkable advancements in understanding the mechanisms underlying biological aging and identified ways to target aging pathways using both novel agents and repurposed therapies. While geroscience researchers currently face significant barriers in bringing therapies through clinical development, proof-of-concept studies, as well as early-stage clinical trials, are underway to assess the feasibility of drug evaluation and lay a regulatory foundation for future FDA approvals in the future.

中文翻译：

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延长人类健康寿命和寿命：研讨会报告

多年来，人们认为衰老过程是不可避免的，与年龄相关的疾病无法预防或逆转。然而，老年科学假说认为，衰老实际上是可塑的，通过针对生物衰老的特征，确实有可能减轻与年龄相关的疾病和功能障碍并延长寿命。因此，老年科学领域的目标是预防多种疾病随着年龄的增长而发展，从而延长健康寿命，降低临终时的发病率。该领域的专家在理解生物衰老的机制方面取得了显着的进展，并确定了使用新型药物和重新调整用途的疗法来靶向衰老途径的方法。虽然老年科学研究人员目前在临床开发中面临重大障碍，但概念验证研究以及早期临床试验正在进行中，以评估药物评价的可行性，并为未来 FDA 批准奠定监管基础。未来。