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Neuronal-enriched extracellular vesicles in individuals with IBS: A pilot study of COMT and BDNF
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2021-09-09 , DOI: 10.1111/nmo.14257
Kristen R Weaver 1 , Maja Mustapic 2 , Dimitrios Kapogiannis 2 , Wendy A Henderson 3
Affiliation  

Irritable bowel syndrome (IBS) is characterized by abdominal pain, bowel habit alterations, and psychiatric comorbidities. Although pathophysiology remains incompletely understood, prior work demonstrates associations with brain-derived neurotrophic factor (BDNF) and catechol-O-methyltransferase (COMT). The purpose of this study was to quantify BDNF and COMT in plasma and in neuronal-enriched extracellular vesicles (nEVs), assess relationships with psychological symptoms, and gain insight on the brain-gut connection in IBS.

中文翻译:

IBS 患者富含神经元的细胞外囊泡:COMT 和 BDNF 的初步研究

肠易激综合征 (IBS) 的特征是腹痛、排便习惯改变和精神合并症。尽管病理生理学仍未完全了解,但先前的工作表明与脑源性神经营养因子 (BDNF) 和儿茶酚-O-甲基转移酶 (COMT) 相关。本研究的目的是量化血浆和富含神经元的细胞外囊泡 (nEV) 中的 BDNF 和 COMT,评估与心理症状的关系,并深入了解 IBS 中的脑-肠连接。
更新日期:2021-09-09
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