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Piperidine nucleus in the field of drug discovery
Future Journal of Pharmaceutical Sciences Pub Date : 2021-09-09 , DOI: 10.1186/s43094-021-00335-y
Mennatallah Mahmoud Abdelshaheed 1 , Iten Mamdouh Fawzy 2 , Khairia Mohamed Youssef 2 , Hussein Ibrahim El-Subbagh 3
Affiliation  

Piperidine is an essential heterocyclic system and a pivotal cornerstone in the production of drugs. Piperidine byproducts showed several important pharmacophoric features and are being utilized in different therapeutic applications. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents. This review article sheds a light on the most recent studies proving the importance of piperidine nucleus in the field of drug discovery.

中文翻译:

药物发现领域的哌啶核

哌啶是一种必不可少的杂环系统,也是药物生产中的关键基石。哌啶副产物显示出几个重要的药效学特征,并被用于不同的治疗应用。哌啶衍生物正以不同的方式用作抗癌、抗病毒、抗疟、抗微生物、抗真菌、抗高血压、镇痛、抗炎、抗阿尔茨海默、抗精神病和/或抗凝剂。这篇综述文章阐明了最近的研究,证明了哌啶核在药物发现领域的重要性。
更新日期:2021-09-09
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