Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal transduction, mitosis, lipid homeostasis, and directed migration, among others. Less well-appreciated are the roles various forms of endocytosis plays in regulating αβ and, especially, γδ T cell functions, such as T cell receptor signaling, antigen discovery by trogocytosis, and activated cell growth. Herein we examine the contribution of both clathrin-mediated and clathrin-independent mechanisms of endocytosis to T cell biology.

中文翻译：

---

T细胞内吞作用的机制和功能

曾经主要被认为是一种中和病原体或促进摄食的手段，现在已知内吞作用可以调节广泛的真核细胞过程。其中包括调节信号转导、有丝分裂、脂质稳态和定向迁移等。鲜为人知的是各种形式的内吞作用在调节 αβ 尤其是 γδ T 细胞功能中所起的作用，例如 T 细胞受体信号传导、通过吞噬作用发现抗原和活化细胞生长。在这里，我们检查了网格蛋白介导的和网格蛋白独立的内吞机制对 T 细胞生物学的贡献。