Transmembrane proteins located within biological membranes play a crucial role in a variety of important cellular processes, such as energy conversion and signal transduction. Among them, ion channel proteins that can transport specific ions across the biological membranes are particularly important for achieving precise control over those processes. Strikingly, approximately 20% of currently approved drugs are targeted to ion channel proteins within membranes. Thus, synthetic molecules that can mimic the functions of natural ion channel proteins would possess great potential in the sensing and manipulation of biologically important processes, as well as in the purification of key industrial materials.

中文翻译：

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多嵌段两亲分子形成的超分子跨膜离子通道

位于生物膜内的跨膜蛋白在各种重要的细胞过程中起着至关重要的作用，例如能量转换和信号转导。其中，可以跨生物膜运输特定离子的离子通道蛋白对于实现对这些过程的精确控制尤为重要。引人注目的是，目前批准的药物中约有 20% 的目标是膜内的离子通道蛋白。因此，可以模拟天然离子通道蛋白功能的合成分子在生物重要过程的传感和操作以及关键工业材料的纯化方面具有巨大的潜力。