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Sodium sulphide promoted synthesis of fused quinoline at room temperature
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2021-09-09 , DOI: 10.1039/d1ob01085a
Rashmi Singh 1 , Vishal Prasad Sharma 1 , Priyanka Yadav 1 , Priyanka Sonker 1 , Radhey Mohan Singh 1 , Ashish Kumar Tewari 1
Affiliation  

A novel, simple and eco-friendly strategy for the synthesis of thiopyrano[4,3-b]quinolin-1-ones and pyrrolo[3,4-b]quinolin-1-ones from 2-alkynylquinoline-3-carbonitriles and sodium sulphide (Na2S·9H2O) under catalyst-free conditions at room temperature has been described. In this reaction, a readily available inorganic salt (Na2S·9H2O) serves as the sulphur source and leads to the generation of diverse functionalized thiopyrano[4,3-b]quinolin-1-ones and pyrrolo[3,4-b]quinolin-1-ones in moderate to excellent yields through sulfuration, annulation, and aerial oxidation.

中文翻译:

硫化钠促进室温下稠喹啉的合成

一种由 2-炔基喹啉-3-腈和钠合成噻吩并[4,3- b ]喹啉-1-酮和吡咯并[3,4- b ]喹啉-1-酮的新型、简单且环保的策略已经描述了在室温下无催化剂条件下的硫化物 (Na 2 S·9H 2 O)。在这个反应中,一种容易获得的无机盐(Na 2 S·9H 2 O)作为硫源,导致生成多种官能化的硫代吡喃并[4,3 - b ]喹啉-1-酮和吡咯并[3,4 - b ]quinolin-1-ones 通过硫化、环化和空气氧化获得中等至极好的产率。
更新日期:2021-09-09
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