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Development and validation of a UPLC-MS/MS method for the quantification of isothiazolinones in the composition and emissions from consumer products
Analytical and Bioanalytical Chemistry ( IF 4.3 ) Pub Date : 2021-09-08 , DOI: 10.1007/s00216-021-03627-7
Léa Ducup de Saint Paul 1, 2 , Sylvain Ravier 2 , Henri Wortham 2 , François Maupetit 1 , Mélanie Nicolas 1 , Etienne Quivet 2
Affiliation  

Isothiazolinones, a family of biocides, are used as preservatives for their fungicidal, bactericidal, and algacidal properties. These compounds can be found in a wide range of consumer and building products, such as paints, varnishes, shampoos, and liquid detergents. A robust analytical UPLC-MS/MS method to identify and quantify seven isothiazolinones (MIT, CMI, BIT, MBIT, BBIT, OIT, and DCOIT) in consumer products and their emissions was developed and validated according to ISO/IEC 17025. The limits of detection (LODs) ranged from 0.14 μg L−1 (BIT) to 0.54 μg L−1 (CMI). The method was applied for the quantification of the seven isothiazolinones in four types of consumer products (i.e., cosmetics, air fresheners, cleaning products, and building products) and the indoor emissions from a paint. Matrix effects were observed for the shampoo (63–74%), the shower gel (67–84%), and the ceramic glass cleaner (53–57%). All isothiazolinones indicated by the manufacturer (i.e., MIT, CMI, BIT, OIT, and DCOIT) were detected in the products and successfully quantified by the UPLC-MS/MS method.

Graphical abstract



中文翻译:

开发和验证 UPLC-MS/MS 方法,用于定量消费品中的异噻唑啉酮和排放物

异噻唑啉酮是一类杀菌剂,因其具有杀真菌、杀菌和杀藻的特性而被用作防腐剂。这些化合物可以在广泛的消费品和建筑产品中找到,例如油漆、清漆、洗发水和液体洗涤剂。根据 ISO/IEC 17025 开发和验证了一种稳健的 UPLC-MS/MS 分析方法,用于识别和量化消费品中的七种异噻唑啉酮(MIT、CMI、BIT、MBIT、BBIT、OIT 和 DCOIT)及其排放。检测 (LOD) 范围从 0.14 μg L -1 (BIT) 到 0.54 μg L -1(CMI)。该方法用于定量分析四种消费品(即化妆品、空气清新剂、清洁产品和建筑产品)中的七种异噻唑啉酮以及油漆的室内排放。观察到洗发水 (63–74%)、沐浴露 (67–84%) 和陶瓷玻璃清洁剂 (53–57%) 的基质效应。在产品中检测到制造商指出的所有异噻唑啉酮(即 MIT、CMI、BIT、OIT 和 DCOIT),并通过 UPLC-MS/MS 方法成功定量。

图形概要

更新日期:2021-09-09
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