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Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine
Journal of Saudi Chemical Society ( IF 5.6 ) Pub Date : 2021-09-09 , DOI: 10.1016/j.jscs.2021.101344
Lefeng Liu 1 , Zhiguo Xu 1 , Yang Liu 1 , Zheng-Zhi Yin 2 , Yanshan Sheng 3 , Chengqiang Ding 3 , Yong Kong 3
Affiliation  

Cytarabine (Cyt) encapsulated calcium carbonate (CaCO3) nanospheres were facilely synthesized through a simple co-precipitation method, and the Cyt encapsulated CaCO3 nanospheres (CaCO3/Cyt) were modified by polyacrylic acid (PAA) hydrogels through in situ polymerization of acrylic acid (AA) monomer on the surface of the CaCO3/Cyt. Successful preparation of the Cyt loaded CaCO3/PAA hydrogels were confirmed by the characterization of SEM, TEM and FT-IR. Premature release of Cyt in acidic medium (pH = 1.2) could be effectively circumvented by the introduction of the PAA hydrogels. More importantly, pH-responsive delivery of Cyt from the as-prepared CaCO3/PAA hydrogels could be achieved due to the pH-sensitivity of the PAA. Although the highest swelling ratio of PAA was obtained at pH 7.3 (27.7), the highest cumulative release of Cyt from the carrier was achieved at pH 5.3 (86.75%), which might be attributed to the high stability of CaCO3 at pH 7.3. That is to say, the highest cumulative release of Cyt at pH 5.3 was a compromise by considering the relatively high swelling ratio of PAA and the relatively low stability of CaCO3.



中文翻译:

碳酸钙/聚丙烯酸水凝胶的简便合成,用于阿糖胞苷的 pH 响应递送

通过简单的共沉淀法合成了阿糖胞苷(Cyt)包裹的碳酸钙(CaCO 3)纳米球,并通过聚丙烯酸(PAA)水凝胶通过原位聚合对Cyt包裹的CaCO 3纳米球(CaCO 3 /Cyt)进行了改性。 CaCO 3 /Cyt表面的丙烯酸 (AA) 单体。SEM、TEM 和 FT-IR 的表征证实了负载 Cyt 的 CaCO 3 /PAA 水凝胶的成功制备。通过引入 PAA 水凝胶可以有效地避免 Cyt 在酸性介质 (pH = 1.2) 中的过早释放。更重要的是,从制备的 CaCO 3 中传递 Cyt 的 pH 响应性由于 PAA 的 pH 敏感性,可以实现 /PAA 水凝胶。尽管在 pH 7.3 (27.7) 下获得了最高的 PAA 溶胀率,但在 pH 5.3 (86.75%) 下实现了载体中 Cyt 的最高累积释放,这可能归因于 CaCO 3在 pH 7.3 下的高稳定性。也就是说,考虑到 PAA 相对较高的溶胀率和 CaCO 3相对较低的稳定性,在 pH 5.3 下 Cyt 的最高累积释放是一种折衷。

更新日期:2021-09-21
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