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A Novel Coumarin-based Fluorescent Probe with Aggregation Induced Emission for Detecting CN− and its Applications in Bioimaging
Journal of Fluorescence ( IF 2.7 ) Pub Date : 2021-09-08 , DOI: 10.1007/s10895-021-02817-x
Sha Deng 1 , Qiao Lei 1 , Junzhe Cai 1 , Yuliang Jiang 1 , Jian Shen 1
Affiliation  

Although cyanogen ion (CN) plays important role in industry which also bring acute environmental pollution. More serious, trace CN enters the human body can cause serious consequences and even death. Therefore, it is of great significance to detect trace CN with high sensitivity. Herein, a novel aggregation-induced emission (AIE) probe C-BH was synthesized based on coumarin matrix. Probe C-BH showed high selectivity and sensitivity toward CN by dual channel response due to the excited state intramolecular proton transfer (ESIPT). The low detection limit was calculated to be 0.05 µM. Moreover, probe C-BH was successfully used for imaging CN in living cells and zebrafish due to its low toxicity and excellent optical properties.



中文翻译:

一种新型聚集诱导发射的香豆素荧光探针检测CN-及其在生物成像中的应用

虽然氰离子(CN -)在工业中发挥着重要作用,但也带来了严重的环境污染。更严重的是,微量CN-进入人体会造成严重后果,甚至死亡。因此,高灵敏度检测痕量CN -具有重要意义。在此,基于香豆素基质合成了一种新型聚集诱导发射(AIE)探针C-BH。由于激发态分子内质子转移 (ESIPT),探针 C-BH 通过双通道响应对 CN -显示出高选择性和灵敏度。低检测限计算为 0.05 µM。此外,探针 C-BH 成功用于 CN 成像-由于其低毒性和优异的光学特性,在活细胞和斑马鱼中。

更新日期:2021-09-09
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