AbstractIntroductionExamination of pathologic, anatomic, and cognitive relationships has been limited in primary progressive aphasia (PPA) with underlying Alzheimer's disease (AD) neuropathology.MethodsSpatial relationships between tau positron emission tomography (PET), cortical thickness, age, and naming on the Boston Naming Test (BNT) in PPA with biomarker evidence of AD (PPA‐AD) were examined.ResultsHigher tau PET burden was associated with atrophy and younger age. There was a significant left‐lateralized relationship between lower BNT and more atrophy, and between lower BNT and increased tau burden. Variance in naming was primarily shared between tau and atrophy (51%), but naming was uniquely explained more by atrophy (32%) than tau (16%). Higher left anterior temporal tau burden was associated with greater 1‐year rate of decline in naming.DiscussionPPA‐AD has a similar relationship between abnormal biomarkers as first described in amnestic AD, with differing spatial extent, reflecting the left‐lateralized nature of the language network.

中文翻译：

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阿尔茨海默病失语症变异体中 tau 蛋白负荷、萎缩、年龄和命名之间的关系

摘要介绍对具有潜在阿尔茨海默病 (AD) 神经病理学的原发性进行性失语 (PPA) 的病理、解剖和认知关系的检查受到限制。方法研究了 tau 正电子发射断层扫描 (PET)、皮质厚度、年龄和 PPA 中波士顿命名测试 (BNT) 命名与 AD 生物标志物证据 (PPA-AD) 之间的空间关系。结果较高的 tau PET 负荷与萎缩和年轻化有关。较低的 BNT 与更多的萎缩之间以及较低的 BNT 与增加的 tau 负荷之间存在显着的左偏相关性。命名差异主要存在于 tau 和萎缩 (51%) 之间，但命名的唯一解释是萎缩 (32%) 多于 tau (16%)。较高的左前颞 tau 负担与较高的 1 年命名下降率相关。讨论PPA-AD 与遗忘性 AD 中首次描述的异常生物标志物之间的关系类似，但空间范围不同，反映了语言网络的左偏性质。