Porous inorganic materials play an important role in adsorbing targeted analytes and supporting efficient reactions in analytical science. The detection performance relies on the structural properties of porous materials, considering the tunable pore size, shape, connectivity, etc. Herein, we first clarify the enhancement mechanisms of porous materials for bioanalysis, concerning the detection sensitivity and selectivity. The diagnostic applications of porous material-assisted platforms by coupling with various analytical techniques, including electrochemical sensing, optical spectrometry, and mass spectrometry, etc., are then reviewed. We foresee that advanced porous materials will bring far-reaching implications in bioanalysis toward real-case applications, especially as diagnostic assays in clinical settings.

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用于生物分析和诊断应用的多孔无机材料

多孔无机材料在吸附目标分析物和支持分析科学中的高效反应方面发挥着重要作用。检测性能依赖于多孔材料的结构特性，考虑可调孔径、形状、连通性等。在此，我们首先阐明多孔材料用于生物分析的增强机制，涉及检测灵敏度和选择性。然后回顾了多孔材料辅助平台与各种分析技术相结合的诊断应用，包括电化学传感、光谱法和质谱法等。我们预见到，先进的多孔材料将对实际案例应用的生物分析产生深远影响，尤其是作为临床环境中的诊断分析。