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Impact of sociodemographic factors on early mortality in acute promyelocytic leukemia in the United States: A time-trend analysis
Cancer ( IF 6.2 ) Pub Date : 2021-09-08 , DOI: 10.1002/cncr.33914
Omer H Jamy 1 , Aditi Dhir 2 , Luciano J Costa 1 , Ana C Xavier 2
Affiliation  

The survival of patients with acute promyelocytic leukemia (APL) has dramatically improved with the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, because of the complexity of the initial management, early mortality (EM) remains a major contributor to treatment failure. It is less known whether advances in treatment, urgent access to specialized care, and broad availability of ATRA/ATO have reduced EM in the last 2 decades. Furthermore, the influence of sociodemographic factors on the risk of EM also remains unclear.

中文翻译:

社会人口因素对美国急性早幼粒细胞白血病早期死亡率的影响:时间趋势分析

使用全反式维甲酸 (ATRA) 和三氧化二砷 (ATO) 可显着提高急性早幼粒细胞白血病 (APL) 患者的生存率。然而,由于初始管理的复杂性,早期死亡率 (EM) 仍然是导致治疗失败的主要原因。在过去的 20 年中,治疗的进步、紧急获得专业护理以及 ATRA/ATO 的广泛可用性是否减少了 EM 的情况鲜为人知。此外,社会人口因素对 EM 风险的影响也仍不清楚。
更新日期:2021-09-08
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