To understand the information encoded in a connection between the neurons, postsynaptic current (PSC) has been widely measured as a primary index of synaptic strength in the field of neurophysiology. Although several automatic detection methods for PSCs have been proposed to simplify a workflow in the analysis, repetitive steps such as quantification and management of PSC data should be still performed with much effort. Here, we present Minhee Analysis Package, an integrated standalone software package that is capable of detecting, sorting, and quantifying PSC data. First, we developed a stepwise exploratory algorithm to detect PSC and validated our detection algorithm using the simulated and experimental data. We also described all the features and examples of the package so that users can use and follow them properly. In conclusion, our software package is expected to improve the convenience and efficiency of neurophysiologists to analyze PSC data by simplifying the workflow from detection to quantification. Minhee Analysis Package is freely available to download from http://www.github.com/parkgilbong/Minhee_Analysis_Pack .

中文翻译：

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Minhee Analysis Package：用于检测和管理自发突触事件的集成软件包

为了理解在神经元之间的连接中编码的信息，突触后电流 (PSC) 已被广泛测量为神经生理学领域突触强度的主要指标。尽管已经提出了几种用于 PSC 的自动检测方法来简化分析中的工作流程，但仍应努力执行重复步骤，例如 PSC 数据的量化和管理。在这里，我们介绍 Minhee 分析包，这是一个集成的独立软件包，能够检测、排序和量化 PSC 数据。首先，我们开发了一种逐步探索算法来检测 PSC，并使用模拟和实验数据验证了我们的检测算法。我们还描述了该软件包的所有功能和示例，以便用户可以正确使用和遵循它们。综上所述，我们的软件包有望通过简化从检测到量化的工作流程来提高神经生理学家分析 PSC 数据的便利性和效率。Minhee 分析包可从 http://www.github.com/parkgilbong/Minhee_Analysis_Pack 免费下载。