Weight changes are common among breast cancer patients. The majority of studies to date have focused on weight gain after a breast cancer diagnosis and its implications on health in survivors. Fewer studies have examined weight loss and its related characteristics. Weight changes have been reported to be influenced by several factors such as age, treatment, stage and pre-diagnostic weight. We evaluated weight changes during key treatment time points in early stage breast cancer patients. We characterized 389 female patients diagnosed in Hawaii with early stage breast cancer from 2003 to 2017 in the Multiethnic Cohort (MEC) linked with Kaiser Permanente Hawaii electronic medical record data. We evaluated weight changes from surgery to 4 years post-diagnosis with six time points along a patient’s treatment trajectory (chemotherapy, radiation, endocrine, or surgery alone) and annually thereafter, adjusting for age, race/ethnicity and initial body mass index (BMI). We found key time points of significant weight change for breast cancer patients according to their adjuvant treatment. In patients who had surgery alone (S), surgery-radiation (SR), or surgery-endocrine therapy (SE), the majority of patients had stable weight, although this consistently decreased over time. However, the percentages of patients with weight loss and weight gain during this time steadily increased up to 4 years after initial surgery. Weight loss was more common than weight gain by about 2 fold in these treatment groups. For patients with surgery-chemotherapy (SC), there was significant weight loss seen within the first 3 months after surgery, during the time when patients receive chemotherapy. And this weight loss persisted until year 4. Weight gain was less commonly seen in this treatment group. We identified key time points during breast cancer treatment that may provide a therapeutic window to positively influence outcomes. Tailored weight management interventions should be utilized to promote overall health and long term survivorship.

中文翻译：

---

不同乳腺癌患者队列的体重随治疗而变化

体重变化在乳腺癌患者中很常见。迄今为止，大多数研究都集中在乳腺癌诊断后的体重增加及其对幸存者健康的影响。很少有研究探讨体重减轻及其相关特征。据报道，体重变化受到年龄、治疗、分期和诊断前体重等多种因素的影响。我们评估了早期乳腺癌患者在关键治疗时间点的体重变化。我们对 2003 年至 2017 年在夏威夷诊断为早期乳腺癌的 389 名女性患者进行了特征分析，这些患者属于与 Kaiser Permanente Hawaii 电子病历数据相关的多种族队列 (MEC)。我们评估了从手术到诊断后 4 年的体重变化，沿着患者的治疗轨迹（化疗、放疗、内分泌或单独手术）的六个时间点进行评估，此后每年根据年龄、种族/民族和初始体重指数 (BMI) 进行调整）。我们根据乳腺癌患者的辅助治疗发现了体重显着变化的关键时间点。在仅接受手术（S）、手术放射治疗（SR）或手术内分泌治疗（SE）的患者中，大多数患者体重稳定，尽管体重随着时间的推移而持续下降。然而，在初次手术后 4 年内，在此期间体重减轻和体重增加的患者比例稳步上升。在这些治疗组中，体重减轻的情况比体重增加的情况常见约两倍。对于接受手术联合化疗 (SC) 的患者，术后前 3 个月内即接受化疗期间体重明显下降。这种体重减轻一直持续到第四年。体重增加在该治疗组中不太常见。我们确定了乳腺癌治疗期间的关键时间点，这可能提供一个治疗窗口来积极影响结果。应利用量身定制的体重管理干预措施来促进整体健康和长期生存。